Publications in Scientific Journals:
D. K. Minster, U. Jordis, D. L. Evans, S. M. Hecht:
"Thiazoles from cysteinyl peptides";
Journal of Organic Chemistry,
Glutathione deriv. I underwent dehydrative cyclization to thiazoline II which was oxidized by NiO2 to thiazole III (R = Et, R1 = Ac) which was hydrolyzed to III (R = R1 = H), an amino acid deriv. from the mushroom Xerocomus subtomentosus. Three thiazoline derivs. were oxidized by NiO2 to their corresponding thiazoles, whereas 5 other heterocyclic compds. were also dehydrogenated with NiO2. The thiazoline ring of phleomycin A2 was oxidized by NiO2 to the thiazole ring of bleomycin A2.
Created from the Publication Database of the Vienna University of Technology.