Publications in Scientific Journals:
F. Sauter, U. Jordis, S. Tanyolac:
"Synthesis of novel quinolone drugs. Part 3. Thieno[2,3-f]quinolinecarboxylic acids";
Benzo[b]thiophene I (R = H) was cyclized with glycerin by the Skraup reaction to give thieno[2,3-f]quinoline II. I (R = H) was converted to I [R = CH:C(CO2Et)2], which was cyclized by the Gould-Jacobs reaction to give title compd. III. Penicillin derivs. IV and V were also prepd. The in vitro antibacterial activities of IV and V were inferior to those of known bactericides, e.g., nalidixic acid.
Created from the Publication Database of the Vienna University of Technology.