Publications in Scientific Journals:
M. Treu, U. Jordis, K. Mereiter:
"12H--benzothiepino[6,5a,5-bc]benzofuran: synthesis of a sulfur-analog of galanthamine";
An analog of the anti-Alzheimer drug galanthamine I, carrying a SO2-moiety instead of an amino-functionality, has been synthesized as a racemic mixt. using tandem cyclization techniques to form a new four membered heterocyclic ring system. I was deviod of any noticeable acetylcholin- (AChE) or butyrylcholinesterase (BuChE) inhibition confirmed the expectation that the amine functionality is essential for the AChE or BuChE inhibitory activity of galanthamine.
Created from the Publication Database of the Vienna University of Technology.